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Scientist I (Scientific)

Location: Cambridge, Massachusetts
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We are seeking an energetic and motivated Scientist with deep scientific and technical expertise in immunology or immune-oncology with a track record of scientific excellence to join our team in Cambridge, MA USA. As a Scientist in Breakthrough Lab you will be a key member of a team focused on supporting immunology and immuno-oncology projects through the drug discovery and development process. You will bring your expertise to support translational studies towards the identification of clinical candidates and deliver datasets that will have direct impact on immune-oncology therapeutics. The candidate will have a unique opportunity to create innovative medicines for patients and could potentially be offered a permanent position in a promising start-up biotech company.

Job Summary
• Displays strong investigative or technological orientation with independence of experimental design in both cases by performing complex analytical procedures and implementing new techniques.
• May oversee lower level researchers in the execution, design and interpretation of experiments.
• Contributes to the scientific literature, external conferences and/or scientific patents, where applicable.
• Provides consultation to internal Research and Development groups.
• May lead some aspect of a project in a small lab group.
• Identify and develop assays to evaluate the therapeutic effects of clinical candidates in relevant in vitro and in vivo models

Key Responsibilities
• Develops strategy and technologies to conduct experiments and analytical procedures, applying a wide variety of scientific principles and concepts.
• Evaluates and defines appropriate approaches.
• Determines new methods and develops new procedures for accomplishing work.
• Serves as internal consultant in area of scientific expertise.
• Contributes to the completion of specific programs and projects.
• Interact with various cross-function teams and function in a project leadership role.

Basic Qualifications
• PhD with a minimum of 3 years of relevant experience in field of immunology or immune-oncology
• Molecular biology: molecular cloning, site-directed mutagenesis
• Cell Culture: primary cell isolation, stable cell line
• Protein purification: affinity, IEX, SEC and HIC; familiarity with GE AKTA system; automated liquid handling
• Biochemical and biophysical characterization: SDS-PAGE, Western blot, ELISA
• Cell-based assay: Multi-spectral flow cytometry
• Deep understanding of biologics drug development and experience in target validation, PK, PK/PD, in vitro and in vivo assays is preferred
• Excellent presentation, written, and oral communication skills.

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