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Scientist III/Senior Principal Scientist, Lab Head

Location: Cambridge, Massachusetts
Job Category:

Senior Principal Scientist, Lab Head-On-SITE

Position Overview:

Sanofi is a global health care leader that is transforming the oncology research and development
paradigm. Our goal is to create a dynamic and exciting environment that is dedicated to cutting-edge
science and delivering novel life-saving therapies to cancer patients. Our ability to execute on this vision
depends on the knowledge, dedication, and innovation of employees throughout the organization. As a
part of our team, you will have an opportunity to work with talented and passionate colleagues in Sanofi
Oncology Research which is a global organization located in two sites: Cambridge, Massachusetts and
Vitry-sur-Seine, France. We are seeking a highly motivated, innovative & experienced scientist with a
strong background and proven track record in the fields of oncology, immunology & pharmacology.
Significant experience with both small molecules and biologics is required. Experience with immune cell
biology and cell assay techniques is required. The candidate will independently design and execute in vivo
studies to evaluate new targets and advance new drug candidates in the Oncology portfolio. This will
include developing and characterizing mouse models of cancer, designing and executing PK/PD and in
vivo efficacy studies, and communicating/presenting ideas and data.

Key Responsibilities:

Lead 1-2 technicians, provide management, scientific support and oversee the design and
execution of in vivo studies to advance drug candidates through the pipeline of Sanofi’s
Oncology portfolio.
Develop efficient interactions with collaborators within and outside Oncology.
Provide scientific expertise, establish, and monitor external scientific collaborations, studies
in CROs, monitor & provide critical assessment of competitor activities.
Recognize, assess, and implement scientific trends.
Participate in the development and characterization of novel mouse models for
immunotherapy and molecular oncology, promote establishment, evolution and
characterization of cancer models dedicated to drug discovery and development projects.
Provide and promote support for operational procedures according to Sanofi values, ethics
and security.
Provide management and scientific support to train lab members and promote their career
Prepare publications, research, and clinical/regulatory documentation in accordance with
Sanofi quality standards.

Basic Qualifications:
We are looking for a highly motivated individual with a Ph.D. in Oncology, Immunology or a related
discipline, with a minimum of 5 years of relevant experience in pharmaceutical industry drug discovery and
development with a focus on in-vivo efficacy, pharmacology and PK/PD studies
Scientific understanding of immunology, oncology, biology, biomarker and translatability
between experimental models and human patients.

Demonstrate understanding of multidisciplinary imaging methodologies for real time
assessment of MOA studies, efficacy, pharmacokinetics in vivo and ex vivo analysis.

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