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Scientist II-Formulation Scientist


Location: Waltham, Massachusetts
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Description:
Scientist II – Formulation Scientist
Duties
Responsibilities will include, but are not limit to, the following:
• Provides direct on-site early formulation development support to enable efficacy, PK, and toxicology studies for small molecule Drug Discovery efforts.
• Provides drug substance characterization including crystallinity assessment, solubility determination, and physicochemical stability evaluation.
• Offers solubility enhancement of poor water soluble compounds by applying various solubilization techniques.
• Develops understanding of the impact of physiochemical and solid state properties on drug candidate performance.
• Perform in-silico biopharmaceutical evaluation to support drugability assessment.
• Inform and influence drug discovery team finding new chemical entities with desirable physicochemical and biopharmaceutical properties.
• Recommends potential clinical formulation to the project team based on physicochemical and biopharmaceutical properties of the drug candidate.

Skills
• Knowledge in discovery and preclinical formulation support, preformulation screening, solid state characterization and aiding formulation design. Analytical mindset on analyzing formulation, and hands-on experience on instruments such as HPLC, dissolution, microscope, and particle size analysis,
• Self-motivated with capabilities in executing tasks independently, following protocols accurately, managing time efficiently, delivering formulations accurately and timely, and collaborating with other team members professionally.
• Good written and verbal communication skills.
• B.S./M.S./Ph.D. in pharmaceutics, pharmaceutical science, pharmaceutical chemistry or related scientific discipline required.
• Prefer 1 to 2 years of relevant experience in discovery and preclinical support, preformulation screening, early formulation development, and solid state characterization in the pharmaceutical industry.
Education
• Minimum BS, prefer MS or PhD, in Pharmaceutics, pharmaceutical science, pharmaceutical chemistry or related scientific discipline required.

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